There's a crazy story in here where Sytse invested in a click chemistry cancer research startup (Shasqi) in 2017 and ends up becoming a customer six years later.
I think you’d find Dr. Richard Scolyer’s story really relatable. He’s an Australian cancer expert who, along with his colleague, is using himself as "patient zero" for a world-first treatment for his own brain cancer. They’re basically doing the research and the treatment in parallel to find a new way forward: https://www.abc.net.au/news/2025-10-30/dr-richard-scolyer-sp...
This is the most supremely motivating post I've seen in a long time. I know what it is to be diagnosed with cancer, being rushed to surgery - it's amazing how quickly the medical-industrial complex can move once you've got a diagnosis (at least in Australia). I had a short period of contemplating terminally, because cancer claimed the life of most of my family. Thankfully, after surgery it was gone.
To see Sid use his motivation and resources to solve his own problem is the core message (IMHO) of the hacker community.
It makes me look at my own problem (Peyronies) in a different light; a disease which has affected my life in ways which cannot be overstated. Yet, all the money in the world right now can't fix Peyronies - yet in reading his journey my mind has been changed about this.
His slide title: "I'll talk to anyone, I'll go anywhere, and I can be there anytime" is certainly the mindset!
Thanks for posting this - I'm inspired to take similar action for Peyronie's. Anything is possible.
This is fantastic and I would do something similar if I had the same resources.
Whole genome sequencing and single cell sequencing are actually surprisingly inexpensive (compared to the cost of almost any cancer treatment) and there is a good argument that we should do this by default for any type of cancer for which there are not effective treatments.
I would encourage all patients to learn as much as possible about their own diagnosis. There may be clinical trials available in another centre that your clinician is not aware of or tumour-agnostic trials that target specific mutations that are present in a range of different cancers.
There is a good argument for allowing patients to try experimental treatments once standard treatments are exhausted. The provider liability issues could easily be solved by legislation. A bigger issue is that there will always be people who want to exploit vulnerable cancer patients by charging exorbitant amounts for plausible-sounding treatments which have no evidence base.
As an individual trying multiple experimental treatments at once is the logical approach if there is no other option. However it will not be possible to know which of these is effective and which have caused side effects so to develop more effective treatments we do need structured and carefully controlled clinical trials. Unfortunately there is a huge regulatory burden for any kind of clinical trial at present and this should be massively streamlined for cancer patients where even if the treatments cause harm the alternative is death.
The linked post about his treatment is basically a vanity article; low in useful information, but high in vague assertions and platitudes. There's also a link to a post griping about the red tape someone experienced while trying to self-treat their dog's cancer that's weird. I clearly live in a different world than these people.
Wish the best for Sid! My father was unlucky with his TP53 mutation which resulted in AEL and he passed away suddenly. 100% fit to vanishing away straight in 8 months. It was pretty rough for me especially to see how these doctors (most of them but bot all) are so non-experimental in their attitude.
Sid is right, Staying alive is our own job and definitely what he is doing will give him and his loved ones enough hope to get through this and sometimes he eventually he will get through.
This is one of the most punk rock things humanly possible. "F** the doctors; I'll fix the cancer myself!" Gigantic respect, and massive congrats to being right!
A very motivating post. What he said “It became my own job to keep myself alive. Nobody else was going to do it for me at this point” really stayed with me. It’s powerful to see someone take that level of responsibility in such a difficult situation. I also appreciate how his ability to fund his own treatment can end up benefiting the broader community. Wishing him the best. Cancer is awful, and it just took one of my professor life just a few months ago.
I’m grateful to Sid for what he’s doing—his companies are helping me battle my cancer. I hope more tech entrepreneurs will tackle healthcare and medicine like he is.
This is wonderful but I feel bad for all the people who doesnt have the resources to go through the same. For 99.9% of the population, a diagnostic like his means a really different outcome. I know he is trying to fix this with his investments and companies, but sharing this story could be seen as "boasting"... "I went through this and I survived, while your loved ones wouldn't"
Maybe it's time for him to give the metabolic cancer theory a go and try to bump up his mitochondrial function as much as possible? It's practically untestable due to science testing all compounds in isolation instead of a cocktail over longer period of time that can't be properly controlled even if it might be true. Every single cancer cell has a damaged mitochondria and often switching it properly on leads to cancer cell's apoptosis. He should also take desloratadine as some Swedish hospital observational study showed a significantly increased survivability on all tumor types with it. Some people had success with the combination of DCA, R-ALA, B1 HCl megadoses >2g, CoQ10 + PQQ, glucosidic astaxanthin, nattokinase/serrapeptase/lumbrokinase, low-dose aspirin, pancreatic enzymes and lactoferrin, with complete removal of fructose from the diet (as the cancer explosion can be correlated with years when fructose started getting introduced into diet in large quantities).
Amazing. When motivation meets innovation this is the result. Although a doctor, I cannot follow all the mechanisms. Cancer is a hard problem from the ground up (biology until engineering). You get ill and well multiple times before you or it wins. And the known therapy modalities remain the same since 2500 years (surgery, toxin, burn). Genetics failed loudly in this field. It's all statistics, prevention and luck. Hope all well to the guy.
For those interested in radioligand therapy against FAP antigen expressing cancer, Ratio Therapeutics is recruiting for a Phase 1/2 Open-label Study (NCT07156565).
Eligibility requires history of relapse and refractory soft tissue sarcoma. Recruiting in US and Canada.
Kudos to Sid for trying it and hopefully it benefits others in the long run. Not everyone has the money, will or commitment to do this. My own father died with a battle of myeloma, a blood and bone marrow cancer, after 2 years, it wasn't the disease specifically that got him, it was the secondary conditions that caused irregular heart rhythm and eventually one day it stopped and no one was there to help. 2 stem cell transplants, rounds of chemo, almost full failure of kidneys. The cancer did its job. Ultimately what I'm saying, the medicine gives us time, but no one beats death. Maybe the treatment gives us time to come to terms with that, hopefully my dad did. I was in total denial. Anyway good luck to you Sid.
All the best to all the cancer survivors out there, and to the loved ones who lost them.
The article said he gathered information and that cancer is a disease of information and in next para that the cancer is in remission. How? Did I miss something?
Did cancer got scared of the massive google doc? Just share how if you have found a treatment and if you truly care about people and the world. Just Share
Love seeing Sid posting about this and taking the initiative he has. I wish I'd had the resources and time (and abilities of Sid) when my Dad got ALS considering the relatively poor state of ALS treatments.
This story and the guy curing his dogs cancer leads me to believe what's missing is a jurisdiction that allows people with money to do whatever experiments they want/need to move medicine forward.
It was hard to tell how he is doing and whether any of these treatments are working, but I sincerely hope for a good outcome for him. He has always seen like a genuinely good person. Cancer sucks.
When it comes to cancer, there is an awful lot of legacy thinking and "way things are done" taking lives. Starting with the so called "standard of care", which makes patient lose precious treatment windows while they wait for a possible miracle from "first-line drugs" from thirty and forty years ago which frankly are not that good. But it's hard to reform because the fraction of people who ever think about cancer as a problem to be solved is quite small; and it ought to be far larger, given that cancer is the second or even first leading cause of death across much of the world. I wish Elliot Hershberg every success.
Sid, it’s truly a privilege to work alongside you on this cancer journey. Your innovation and transparency around all things helps pave the way for others in a way like I’ve never seen in 25+ years of healthcare.
Sounds like some lame ass tech founder bullshit if I’ll be honest.
If I had cancer the last think I’d be thinking would be to make a slide deck about it.
Can these robot people come back down to earth and have a genuine human experience for a chance? Not everything has to be framed in the view of a startup company or a data analysis exercise.
Maybe focus on spending time with your family and friends? If they still like you after years of being an insufferable tech bro.
I have a conspiracy theory that people who are overachievers and/or somehow thorns in the side of certain interests get these hard to or borderline incurable illnessess to move them out of the way. Hope I'm wrong...
Love this! This is the way! And he proved it correct.
I remember one time I mentioned this in a casual conversation only to get back very low IQ responses with some fatuous arguments that the tests caused the disease or something.
There was this one guy Tomas something (can't remember the last name, a weird one), doesn't matter, what I do remember is how he was desperately trying to explain how more tests led to more diagnoses and that was ... somehow bad? Lmao.
Something I've observed, I've lived in Canada/US and Latin America, in the former you have to wait months for a CT scan, in the latter you can get it the same day you need it. If the "third-world" can do it, there's no excuse.
He is lucky to have the resources and determination to start his own companies and tackle the problem himself. I wish the majority of tech bros would act in a similar fashion.
The sad truth is, that in most countries, health systems do not allocate sufficient resources or financial support to doctors to correctly diagnose medical conditions accurately as it is not in their economic, interest to do so.
I found another story of using AI for a new vaccine the other day . https://x.com/paul_conyngham/status/2036940410363535823. Its interesting and motivating to see how people are using new technology to save lives regardless of their totally professional background and how informations are useful if you use it the right way. I wish him the best.
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I sincerely hope it works out for him.
To see Sid use his motivation and resources to solve his own problem is the core message (IMHO) of the hacker community.
It makes me look at my own problem (Peyronies) in a different light; a disease which has affected my life in ways which cannot be overstated. Yet, all the money in the world right now can't fix Peyronies - yet in reading his journey my mind has been changed about this.
His slide title: "I'll talk to anyone, I'll go anywhere, and I can be there anytime" is certainly the mindset!
Thanks for posting this - I'm inspired to take similar action for Peyronie's. Anything is possible.
Whole genome sequencing and single cell sequencing are actually surprisingly inexpensive (compared to the cost of almost any cancer treatment) and there is a good argument that we should do this by default for any type of cancer for which there are not effective treatments.
I would encourage all patients to learn as much as possible about their own diagnosis. There may be clinical trials available in another centre that your clinician is not aware of or tumour-agnostic trials that target specific mutations that are present in a range of different cancers.
There is a good argument for allowing patients to try experimental treatments once standard treatments are exhausted. The provider liability issues could easily be solved by legislation. A bigger issue is that there will always be people who want to exploit vulnerable cancer patients by charging exorbitant amounts for plausible-sounding treatments which have no evidence base.
As an individual trying multiple experimental treatments at once is the logical approach if there is no other option. However it will not be possible to know which of these is effective and which have caused side effects so to develop more effective treatments we do need structured and carefully controlled clinical trials. Unfortunately there is a huge regulatory burden for any kind of clinical trial at present and this should be massively streamlined for cancer patients where even if the treatments cause harm the alternative is death.
Sid is right, Staying alive is our own job and definitely what he is doing will give him and his loved ones enough hope to get through this and sometimes he eventually he will get through.
Good on you, Mr. GitLab!
Eligibility requires history of relapse and refractory soft tissue sarcoma. Recruiting in US and Canada.
https://clinicaltrials.gov/study/NCT07156565?tab=researcher#...
All the best to all the cancer survivors out there, and to the loved ones who lost them.
Did cancer got scared of the massive google doc? Just share how if you have found a treatment and if you truly care about people and the world. Just Share
"Bureaucracy" isn't blocking new and better treatments, privatized healthcare and research is.
I hope him all the best.
If I had cancer the last think I’d be thinking would be to make a slide deck about it.
Can these robot people come back down to earth and have a genuine human experience for a chance? Not everything has to be framed in the view of a startup company or a data analysis exercise.
Maybe focus on spending time with your family and friends? If they still like you after years of being an insufferable tech bro.
been thinking about prenuvo all the time now but not sure if thats going to help or make me more paranoid.
> Happy to answer questions!
Are you aware that SARS-CoV-2 is oncogenic, and that repeat exposure increases risk?
Love this! This is the way! And he proved it correct.
I remember one time I mentioned this in a casual conversation only to get back very low IQ responses with some fatuous arguments that the tests caused the disease or something.
There was this one guy Tomas something (can't remember the last name, a weird one), doesn't matter, what I do remember is how he was desperately trying to explain how more tests led to more diagnoses and that was ... somehow bad? Lmao.
Something I've observed, I've lived in Canada/US and Latin America, in the former you have to wait months for a CT scan, in the latter you can get it the same day you need it. If the "third-world" can do it, there's no excuse.
The sad truth is, that in most countries, health systems do not allocate sufficient resources or financial support to doctors to correctly diagnose medical conditions accurately as it is not in their economic, interest to do so.