Scientists invented a fake disease. AI told people it was real (nature.com)

by latexr 92 comments 94 points
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92 comments

[−] simmerup 35d ago
You’ve seen people game adsense

It’s gunna be even wilder when people realise they have an incentive to seed fake information on the internet to game AI product recommendations

I’ve already bought stuff based off of an AI suggestion, I didn’t even consider it would be so easy to influence the suggestion. Just two research papers? Mad.

[−] baobun 35d ago
All it takes to become world champion is a blog.

https://www.bbc.com/future/article/20260218-i-hacked-chatgpt...

[−] ccgreg 35d ago
That's already been happening for more than a year now.
[−] simianwords 35d ago
You are pointing at something that is orthogonal to this paper. The LLM did not randomly recommend or bring this disease up to people - it merely assumed the disease was true when the preprint was pointed at it.
[−] simmerup 35d ago
The LLM bought up the disease because some person put a fake journal in its training data.

If the person put their product as th definitive cure for the made up disease, the LLM probably would have mentioned that too.

> merely assumed the disease was true when the preprint was pointed at it.

What do you mean by preprint pointed at it? It being the disease?

[−] simianwords 35d ago

> The LLM bought up the disease because some person put a fake journal in its training data.

This is not true - the model was not trained on this fake disease. It brought it up because it found it during real time search.

>What do you mean by preprint pointed at it? It being the disease?

On this I'm wrong - it turned out that the model brought up this disease even when not mentioning it explicitly.

[−] simmerup 35d ago
Interesting, will be looking into RAG now. I assume Claude was retrained regularly but Opus for example was last trained August 2025. Way older than I thought it’d be
[−] scoofy 35d ago
It’s not mad… it’s the same damn thing as taking Wikipedia articles as Truth without looking at the citations and verifying them.

AI research is for research, not for blindly accepting. If you’re looking for Truth you need to institute a gatekeeper that does that homework for you.

[−] stingraycharles 35d ago
This is already a thing for a year or so, SEO for AI results to make sure that your products are recommended in ChatGPT.

https://citeworksstudio.com/ is a decent one.

[−] r721 35d ago
This has a name already: "AEO (Answer Engine Optimization)".
[−] vrganj 35d ago
I hate people. Things could be so good if we weren't the way we are.
[−] daoboy 35d ago
It sounds like there wasn't really a counter narrative for the models to learn from. This feature of how llms accumulate information is already being gamed by seeding the internet with preferred narratives.

I'm not sure how many Medium articles, blog posts and reddit threads I need to put out before grok starts telling everyone my widget is the best one ever made, but it's a lot cheaper than advertising.

[−] latexr 35d ago

> I'm not sure how many Medium articles, blog posts and reddit threads I need to put out

Probably not that many.

https://www.anthropic.com/research/small-samples-poison

https://www.bbc.com/future/article/20260218-i-hacked-chatgpt...

[−] sublinear 35d ago
This is the future of advertising, and that was always the true purpose of having LLMs become the first choice for user search.

I seriously do not understand why people keep falling for this. These tools are not made free or cheap out of the kindness of their heart.

[−] eqvinox 35d ago
I'm not sure "being gamed" is the lens I would see this particular instance through. People (some at least) have gotten into their heads that they can ask LLMs objective questions and get objectively correct answers. The LLM companies are doing very little to dissuade them of that belief.

Meanwhile, LLMs are essentially internet regurgitation machines, because of course they are, that's what they do. Which makes them useless for getting "hard truth" answers especially in contested or specialized fields.

I'm honestly afraid of the impact of this. The internet has enough herd bullshit on it as it is. (e.g. antivaxxers, flat earthers, electrosensitivity, vitamin/supplement junk, etc.) We don't need that amplified.

[−] simmerup 35d ago
One impact is the Iran war.

The AI told the government what it wanted to hear contrary to its entire security apparatus, and then they went to war assuming they could win

[−] pjc50 35d ago
People really like using the word "narrative". I guess we're creatures of story.

But this really highlights how much we've been benefiting from living in a high-trust society, where people don't just "go on the internet and tell lies" - filtered by the existing anti-spam and anti-SEO measures intended to cut out the 80% of the internet where people do just make things up to sell products.

LLMs are extremely post-structuralist. They really force the user to decide whether to pick the beautiful eternal fountain of plausible looking text with no ground truth, or a much harder road of distrust, verification, and old-school social proof.

[−] teaearlgraycold 35d ago
I’ve seen an estimate before and it’s in the low 10s.
[−] joenot443 35d ago
I have a friend who recently hit $3000 MRR with a webapp most of us could prototype in a weekend.

Nearly all his traffic comes from ChatGPT

[−] acdha 35d ago
I’m expecting a lot of things like that similar to the 2000s blog boom, only to see it whither even more quickly as the AI companies switch to value extraction mode. You’re really exposed if one company you don’t even have a contract with controls your customer supply.
[−] 21asdffdsa12 35d ago
Can a model not just ignor all things that have no counter-argument by default? Like - if there are not flat earthers, widly debunked, drop the idea of a spherical earth? It only exists if it was fought over?
[−] rcxdude 35d ago
Even if you could do this rigorously (not at all obvious with how LLMs work), it's not a reliable metric: you can easily fabricate debate as well, and in this case the main issue was essentially skimming the surface of the reports and not looking any deeper to see the obvious red flags that it was an april-fools-level fake (which obviously even a person can fall for, but LLMs are being given a far greater level of trust for some reason)
[−] saidnooneever 35d ago
you would just game it the same way then, and how would it know who won an internet argument? how can it prove who is telling the truth and whos... hallucinating?
[−] pjc50 35d ago

> drop the idea of a spherical earth

I think I see a problem here.

[−] vrighter 32d ago
what if it's something correct that doesn't have a counterargument, like "photons with a 450nm wavelength are perceived as red by the average human eye"

And how would it know if a counterargument exists anyway, and if it actually does make sense?

[−] linzhangrun 35d ago
[flagged]
[−] 21asdffdsa12 35d ago
But then mono-opinion- aka certainty - is actually peak uncertainty? Could that number of occurrence be baked into as a sort of detrimental weight?
[−] mrjay42 35d ago
I'm not especially defending AI, but isn't this information like that one time a professor changed the content on Wikipedia to play a big 'gotcha' on his students?

Instead of proving that Wikipedia is "bad", that professor didn't realize he proved that Wikipedia is working as intended: if you write something wrong in Wikipedia, over a certain period of time (yes, it can be long, I know), it will be corrected.

About this article in Nature, if you feed AI incorrect information, it's gonna spit it back at you. When you think about it, when did we say that AI was self correcting?

In a broader logic, imagine we teach kids something false, as an experiment of course. And then we wait a little bit, and we watch some years later how much of this people still repeat the false information they were taught. And then we'd write a paper to say "oh look at those people they're dumb", wouldn't that be a little unfair? even unscientific?

[−] ninjagoo 35d ago
At first I thought this was a Nature paper. Turns out, it's a feature article.

The true test for this would be a blind test that involves human doctors - primary care since that's where something like this fits - exposed to the same data (fake papers), as well as LLMs.

Isn't it interesting that the fake papers made it onto science preprint servers? I didn't think that they were open to posting by random authors and had some basic checks in place. Currently these papers are showing as "withdrawn" on their DOI links [1] [2].

[1] https://doi.org/qzm4 [2] https://doi.org/qzm5

[−] simianwords 35d ago
I think this problem is interesting and it carries over to the general public. Is the general public and are the media outlets also equally skeptical? Are they aware of the distinction between published journals vs preprints?

Take this as an example:

Search for this in google: "ai data centers heat island". Around 80 websites published articles based on a preprint which was largely shown to be completely wrong and misleading.

https://edition.cnn.com/2026/03/30/climate/data-centers-are-...

https://www.theregister.com/2026/04/01/ai_datacenter_heat_is...

https://hackaday.com/2026/04/07/the-heat-island-effect-is-wa...

https://dev.ua/en/news/shi-infrastruktura-pochala-hrity-mist...

https://www.newscientist.com/article/2521256-ai-data-centres...

https://fortune.com/2026/04/01/ai-data-centers-heat-island-h...

You may not believe it but the impact this had on general population was huge. Lots of people took it as true and there seem to be no consequences.

What should be a takeaway for the LLM should also be a takeaway for the media outlets.

[−] austin-cheney 35d ago
I bet you could easily convince LLMs of Dihydrogen-Oxide toxicity.
[−] simianwords 35d ago
This is exaggerated. Here's what happened

Edit: I don't think its exaggerated and I think its important .

1. they invented a new disease and published a preprint (with some clues internally to imply that it was fake)

2. asked the Agent what it thinks about this preprint

3. it just assumed that it was true - what was it supposed to do? it was published in a credentialised way!

It * DID NOT * recommend this disease to people who didn't mention this specific disease. Edit: I'm wrong here. It did pop up without prompting

It just committed the sin of assuming something is true when published.

What is the recommendation here? Should the agent take everything published in a skeptical way? I would agree with it. But it comes with its own compute constraints. In general LLM's are trained to accept certain things as true with more probability because of credentialisation. Sometimes in edgecases it breaks - like this test.

[−] ChrisMarshallNY 35d ago
I wonder if one of the issues is, LLMs treat all data sources equally, or they don’t really weight the reputation properly (pure speculation, based only on seeing the results). I know that a large portion of code out there, is not written by seasoned experts, so rather naive code is the fodder for AI. It often gives me stuff that works great, but is rather “wordy,” or not very idiomatic.

For example, court cases mentioned in fictional accounts. If they are treated as valid, then that could explain some of the hallucinations. I wonder if SCP messes up LLMs. Some of that stuff is quite realistic.

I also suspect that this is a problem that will get solved.

[−] malux85 35d ago
One of the frustrating parts about LLMs is that they are so neutered and conditioned to be politically correct and non-offensive, they are polite more than correct.

Its too easy to "lead the witness" if you say "could the problem be X?" It will do an unending amount of mental gymnastics to find a way that it could be X, often constructing elaborate rube Goldberg type logic rats nests so that it can say those magic words "you're absolutely right"

I would pay a lot of money for a blunt, non-politeness conditioned LLM that I would happily use with the knowledge it might occasionally say something offensive if it meant I would get the plain, cold, hard truth, instead of something watered down, placating, nanny-state robotic sycophant, creating logical spider webs desperate for acceptance, so the public doesn't get their little feelings hurt or inadequacies shown.

[−] thelastgallon 35d ago
If the fake disease is in the medical textbooks, wouldn't doctors have diagnosed for it? For eg: Miasma theory and bloodletting were dominant, yet incorrect, medical doctrines used for centuries until the late 1800s. Miasma proposed that foul-smelling air from rotting matter caused diseases like cholera, while bloodletting (phlebotomy) was used to balance bodily humors.
[−] pu_pe 35d ago
This is partly why this talk about AI "solving science" should be taken with a grain of salt. Here the authors intentionally poisoned the publication record, but there are millions of papers out there that are also garbage, and it would be very hard for either a human or a LLM to distinguish them from actual work.
[−] wiredfool 35d ago
This is a strong contender for an Ignobel.
[−] krilcebre 35d ago
What stops a small, or even a large group of people to intentionally "poison" the LLMs for everyone? Seems to me that they are very fragile, and that an attack like that could cost AI companies a lot. How are they defending themselves from such attacks?
[−] threecheese 35d ago
Yesterday I was asking history questions to an LLM (Perplexity), and one of its sources *was a Facebook* blogspam history feed. If this is feeding back into the training data, we really are cooked.
[−] tossandthrow 35d ago
Seems to be a failure of the publishing system.

For humans, or Ai, to have any knowledge, we need to have trustworthy sources.

Naturally,when you use publishing systems considered trust worthy, that is going to be trusted.

[−] wslh 33d ago
It seems that sites as Wikipedia (including their faults) serves as a good checkpoint of LLMs results.
[−] OutOfHere 35d ago
The authors of all recent bogus papers should be outed and fired. I hope a future AI can identify many of them.
[−] Oras 35d ago
This would work on people too, you can see daily fake info/text/videos and many people believing in them.

LLMs do not think, why this is still hard to understand? They just spit out whatever data they analyse and trained on.

I feel this kind of articles is aimed at people who hate AI and just want to be conformable within their own bias.

[−] andrewstuart 35d ago
Well yes of course.

In the old days of computing people liked to say “garbage in, garbage out”.

[−] _the_inflator 35d ago
Bad. But scientists faked data and told people it wasn’t is ok?

Nature had to recall quite some papers.

I hope that we all keep the balance.

[−] codeulike 35d ago
“Fifty made-up individuals aged between 20 and 50 years were recruited for the exposure group”
[−] gos9 35d ago
And if you put teach a med student the same thing, they’ll also tell people it’s real.

What’s the point?

[−] yewenjie 35d ago
Interestingly ChatGPT right now answered

> Bixonimania is not a real disease. It was deliberately invented by scientists as an experiment to test whether AI systems and researchers would spread false medical information. Here’s the simple explanation ...

[−] aiedwardyi 35d ago
[dead]
[−] fennecbutt 35d ago
This isn't an AI problem...

Clickbait headline.